mole dysplasia

My sister is 23 years old and she was pregnant 28 weeks. Then doctors discovered there is no fetal movement after she complained something’s strange. Ultrasound confirmed fetal death in uterus and labor was induced next day. Her baby was grossly normal, but vasculature of placenta was abnormal. Doctors explained her just saying that was Placental Mesenchymal Dysplasia, or mola, which we don’t understand.

Placental mesenchymal dysplasia (PMD) is also known as pseudo-partial mole. That is a rare disorder with approximately 51 cases reported worldwide. The true incidence of the disorder is still unknown. The disorder is characterized by placentomegaly with markedly hydropic stem villi that resemble a partial mole, without any trophoblastic proliferation. In addition, the karyotype is usually normal and it is thought to have a female predominance, marked as 46 XX. This kind of dysplasia has been found to be associated with Beckwith-Wiedemann syndrome. It is important to distinguish PMD from hydatidiform moles. Various fetal complications have been reported in infants associated with dysplasia. These include intrauterine growth restriction, fetal anemia, and thrombocytopenia, prematurity and intrauterine fetal death. Maternal complications associated with PMD are comparatively rare, and hydatidiform moles require clinical follow-up to document decreasing beta-hCG levels since there is a small risk for persistent gestational trophoblastic disease.

I just thought i would write back to this because on november 10th 2006 i lost my baby at 23 weeks .. it was a boy whom i wanted ever so much but through out the pregnacy they noticed complications i had Placental mesenchymal dysplasia .. and yet i still had no answers i understood tell ur sister to be strong i got a corrinors report the chances of this happening again are less than getting struck my lighting she will never understand why it happen to her and neither will i but please let her know that even tho this is rare other people understand she needs answers im only 19 and i can honestly say i was scared to try again .. but i will and im sure she will too. Good luck