Individuals with a genetic predisposition are exposed to an immunologic trigger that initiates an autoimmune process, resulting in a gradual decline in beta cell mass. The downward slope of the beta cell mass varies among individuals. This progressive impairment in insulin release results in diabetes when 80% of the beta cell mass is destroyed. A "honeymoon" phase may bee seen in the first 1 or 2 years after the onset of diabetes and is associated with reduced insulin requirements.
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